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AdipoGen Retatrutide sodium salt
Supplier: AdipoGen AGCP30044M025
Chemical/Peptide. CAS 2381089-83-2 free acid. Formula C221H342N46O68 . Na. MW 4731.4 . 23.0. Retatrutide is a novel triple agonist peptide of the glucagon receptor GCGR, glucose-dependent insulinotropic polypeptide receptor GIPR and glucagon-like peptide-1 receptor GLP-1R. Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research. Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor GIPR or the GLP-1R. Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes T2D, stimulating insulin and suppressing glucagon secretion in a glucose-dependent manner.
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