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Vector Biolabs Retinoid X receptor, gamma Adenovirus (Ad-RXRg)
Supplier: Vector Biolabs 1590
Retinoids are metabolites of vitamin A (retinol) that represent an important group of signaling molecules during vertebrate development and tissue differentiation. Retinoic acid receptors (RARs) include RARα, RARβ and RARγ, each of which has a high affinity for all transretinoic acids. Members of the retinoid X receptor (RXR) family, RXRα, RXRβ1, RXRβ2 and RXRγ, are activated by 9-cis-retinoic acid, a stereo- and photoisomer of all transretinoic acids that is expressed in vivo in both liver and kidney and may represent a widely used hormone. The RAR-related orphan nuclear receptors (ROR) bind DNA as monomers and include RORα, RORβ and RORγ. DAX-1 binds to retinoic acid response elements to mediate transcription. FXR (activated by farnesol and related metabolites) binds RXR to form a heterodimer, which subsequently binds IR-1 elements.
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