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Apexbio Technology LLC Reversine 656820-32-5 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A37605.1

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Reversine (CAS 656820-32-5) is a small molecule inhibitor targeting Aurora kinases a family of serine/threonine kinases involved in mitotic progression Reversine inhibits Aurora kinase A B and C with IC50 values of 150 nM 500 nM and 400 nM respectively In vitro studies show reversine can induce dedifferentiation of murine myoblast cells and possesses regenerative potential Additionally reversine displays anti-tumor effects by suppressing the expression of Aurora kinases thus disrupting cell-cycle progression In cervical carcinoma mouse models (U14 cells) reversine combined with aspirin synergistically decreases tumor growth highlighting reversine s value for cancer biology research

Catalog No. 50-000-64365


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