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AdipoGen RF-22c [5-Lipoxygenase Inhibitor] (2 mg)
SDP

Supplier:  AdipoGen AGCR13653M002

Encompass_Preferred

Chemical. CAS: 1680206-61-4. Formula: C20H32O4. MW: 336.5. Synthetic. Selective and reversible potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions. Potently inhibits 5-LO product synthesis intact human leukocytes, such as neutrophils and monocytes (IC50>22nM) and in cell-free assays (IC50>140nM) without affecting 12/15-LOs, cyclooxygenase (COX)-1/2 or arachidonic acid release. Anti-inflammatory compound. Shows pronounced effectiveness in different models of inflammation in vivo at 0.1 mg/kg; i.p. Impaired (I) bronchoconstriction in ovalbumin-sensitized mice challenged with acetylcholine, (II) exudate formation in carrageenan-induced paw edema and (III) zymosan-induced leukocyte infiltration in air pouches.

Catalog No. 50-205-4028


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