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Apexbio Technology LLC RGFP966 1357389-11-7;1396841-57-8 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A88035.1

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RGFP966 is a selective inhibitor targeting histone deacetylase 3 (HDAC3) demonstrating an IC50 value of approximately 80 nM HDAC3 a Class I histone deacetylase regulates DNA transcription and influences chromatin structure replication and DNA repair It negatively regulates cognitive mechanisms such as learning and memory processes RGFP966 selectively inhibits HDAC3 without affecting other HDAC isoforms at concentrations up to 15 M as demonstrated by substrate-dependent assays In preclinical research RGFP966 has been utilized to investigate HDAC3 s role in neural functions particularly object recognition memory and to examine cellular effects including growth inhibition and apoptosis induction in models of cutaneous T-cell lymphoma

Catalog No. 50-000-62121


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