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Eurofins Discoverx ChemiScreen Rhesus Macaque CCR5 Chemokine Receptor Stable Cell Line, 2 vials. (HTS010C)
Supplier: Eurofins Discoverx HTS010C
The ChemiScreen Rhesus Macaque CCR5 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. MIP, RANTES) based activation of CCR5 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR5 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR5, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the rhesus macaque version of the protein. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
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