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Cayman Chemical Rheum hotaoense Astrngn 25mg
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Supplier:  Cayman Chemical 2797925 MG

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A dual inhibitor of Aurora kinase (Kds 7 5 and 48 nM for Aurora A and B respectively) and FLT3 (Kds 6 2 38 and 14 nM for wild-type FLT3ITD and FLT3D835Y respectively) inhibits the activity of 22 additional kinases by 90 in a panel of 386 nonmutant kinases at 1 UM inhibits cell growth of SW620 HCT116 MOLM-13 and MV4-11 cancer cells (GI50s 1 0 3 0 1 and 0 3 UM respectively) oral administration reduces tumor growth by 58 in an MV4-11 mouse xenograft model at 50 mg/kg

Catalog No. 50-294-1702


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