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Medchemexpress LLC Rho-Kinase-IN-2 | 2573071-18-6 | C20H25FN4O2 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY150640100MG

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Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and CNS-penetrant Rho Kinase (ROCK) inhibitor with a ROCK2 IC50 of 3 nM, making it suitable for Huntington's research. It increases AKT phosphorylation and decreases MYPT1 phosphorylation both in vitro and in vivo. This product is intended for research use only.

  • Orally active, selective, and CNS-penetrant ROCK inhibitor
  • Targeted inhibition of ROCK2 with an IC50 of 3 nM
  • Increases AKT phosphorylation and decreases MYPT1 phosphorylation in A7r5 and PANC1 cells
  • Demonstrates dose- and time-dependent ROCK1 and ROCK2 target engagement in vivo
  • Shows excellent tolerability in mouse models
  • Decreases mean arterial, systolic, and diastolic blood pressure and heart rate in CD1 mice

Catalog No. 50-003-75180


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