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Medchemexpress LLC Rho-Kinase-IN-2 | 2573071-18-6 | C20H25FN4O2 | 50 MG
Supplier: Medchemexpress LLC HY15064050MG
Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and CNS-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50 = 3 nM). It can be used in Huntington's research. In vitro studies show it increases AKT phosphorylation and decreases MYPT1 phosphorylation. In vivo, it demonstrates dose- and time-dependent ROCK1 and ROCK2 target engagement and tolerability in mouse models. Oral administration decreases mean arterial, systolic, and diastolic blood pressure.
- Orally active, selective, and CNS-penetrant Rho Kinase (ROCK) inhibitor
- ROCK2 IC50 of 3 nM
- Increases AKT phosphorylation and decreases MYPT1 phosphorylation in A7r5 and PANC1 cells
- Demonstrates dose- and time-dependent ROCK1 and ROCK2 target engagement in mice
- Used in Huntington's research
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