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STEMCELL Technologies Rho Kinase Inhibitor IV (Dihydrochloride), Size: 1 mg
Supplier: STEMCELL Technologies 73804
Inhibit Rho-associated coiled-coil containing protein kinase 2 (ROCK2) with Rho Kinase Inhibitor IV (Tamura et al. Biochim Biophys Acta, 2005). This glycyl analog of Fasudil plays an important role in stem cell renewal, smooth muscle contraction, cell adhesion, and proliferation (Narumiya et al. Cancer Metastasis Rev, 2009; Olson. Curr Opin Cell Biol, 2008; Watanabe et al. Nat Biotechnol, 2007). Rho Kinase Inhibitor IV is more potent than other ROCK inhibitors, including Y-27632 and Fasudil. It impairs primitive gut tube development including midgut elongation in Xenopus embryos (Reed et al. Dev Dyn, 2009), promotes neurite growth in primary rat neuronal cultures (Al-Ali et al.), and also reduces intraocular pressure in a rabbit model of glaucoma (Tamura et al. Biochim Biophys Acta, 2005). Rho Kinase Inhibitor IV is supplied as the dihydrochloride salt of the molecule with ≥ 98% purity; Molecular weight 449.4 g/mol; CAS Number 67-56-1. Visit STEMCELL.com for more information.
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