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Cayman Chemical RhodamIn 123chlorIde 100mg

Supplier: Cayman Chemical 16672100 MG

An a2-AR agonist (Kis 61.66 69.18 and 134.9 nM for a2A- a2B- and a2C-ARs respectively) stimulates [35S]GTPYS binding to HEK293 cell membranes expressing human receptors (EC50s 26.92 56.23 and 912.01 nM for a2A- a2B- and a2C-ARs respectively) binds to I1-imidazoline sites in a variety of cell and tissue types (Kds 4-15 nM) induces relaxation of isolated mesenteric artery rings precontracted with norepinephrine at 10 M induces membrane hyperpolarization and reduces norepinephrine-induced depolarization in isolated mesenteric artery rings at 10 M reduces mean blood pressure and heart rate when administered via microinjection to the NRL of anesthetized normotensive cats at 0.1 and 1 g/kg
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