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Medchemexpress LLC Rhosin hydrochloride | 1281870-42-5 | 99.9% | 394.86 | 100 MG
Supplier: Medchemexpress LLC HY12646100MG
Rhosin hydrochloride is a potent and specific inhibitor of the RhoA subfamily of Rho GTPases. It specifically binds to RhoA to inhibit RhoA-GEF interaction and does not interact with Cdc42 or Rac1. This compound induces cell apoptosis and promotes stress resiliency by enhancing D1-MSN plasticity and reducing hyperexcitability.
- Potent and specific RhoA subfamily Rho GTPases inhibitor
- Induces cell apoptosis
- Promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability
- Dose-dependently reduces RhoA and p-MLC1 activities of mammospheres
- Decreases size and reduces number of mammospheres in cells
- Prevents social avoidance and blocks sucrose preference deficits in mice
- Attenuates stress-induced social avoidance
- Blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs)
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