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Medchemexpress LLC Rhosin hydrochloride | 1281870-42-5 | 99.9% | 394.86 | 100 MG
SDP

Catalog No. 5000438198
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Rhosin hydrochloride is a potent and specific inhibitor of the RhoA subfamily of Rho GTPases. It specifically binds to RhoA to inhibit RhoA-GEF interaction and does not interact with Cdc42 or Rac1. This compound induces cell apoptosis and promotes stress resiliency by enhancing D1-MSN plasticity and reducing hyperexcitability.

  • Potent and specific RhoA subfamily Rho GTPases inhibitor
  • Induces cell apoptosis
  • Promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability
  • Dose-dependently reduces RhoA and p-MLC1 activities of mammospheres
  • Decreases size and reduces number of mammospheres in cells
  • Prevents social avoidance and blocks sucrose preference deficits in mice
  • Attenuates stress-induced social avoidance
  • Blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs)

Catalog No. 50-004-38198 Supplier Medchemexpress LLC Supplier No. HY12646100MG
May include imposed supplier surcharges.
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Rhosin hydrochloride is a potent and specific inhibitor of the RhoA subfamily of Rho GTPases. It specifically binds to RhoA to inhibit RhoA-GEF interaction and does not interact with Cdc42 or Rac1. This compound induces cell apoptosis and promotes stress resiliency by enhancing D1-MSN plasticity and reducing hyperexcitability.

  • Potent and specific RhoA subfamily Rho GTPases inhibitor
  • Induces cell apoptosis
  • Promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability
  • Dose-dependently reduces RhoA and p-MLC1 activities of mammospheres
  • Decreases size and reduces number of mammospheres in cells
  • Prevents social avoidance and blocks sucrose preference deficits in mice
  • Attenuates stress-induced social avoidance
  • Blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs)

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