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Cayman Chemical RhosInhydrochlorIde 10mg
Supplier: Cayman Chemical 3641510 MG
An inhibitor of the Rho-GEF protein-protein interaction; inhibits RhoA activity at 10 and 30 µM; selectively reduces the number and size of MCF-7 breast cancer cell mammospheres over MCF-10A non-cancerous cell mammospheres; inhibits migration and invasion of MCF-7 cells and human mammary epithelial cells expressing RhoC; increases neurite outgrowth in PC12 cells at 30 µM; prevents social defeat stress-induced hyperexcitability and increases spine density in D1-MSNs when administered post-social defeat stress in a mouse model of depression at 40 mg/kg; prevents social defeat stress-induced social avoidance and reductions in sucrose preference in a mouse model of depression
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