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Medchemexpress LLC Ribociclib hydrochloride | 1211443-80-9 | >99.9% | 471.00 | 10 MG
Supplier: Medchemexpress LLC 10MGHY15777A
Ribociclib hydrochloride is an ATP-competitive and orally active CDK4/6 inhibitor designed for research use. It effectively crosses the blood-brain barrier and demonstrates potent inhibitory activity against CDK4 and CDK6.
- ATP-competitive and orally active CDK4/6 inhibitor
- Crosses the blood-brain barrier
- IC50 values of 10 nM for CDK4 and 39 nM for CDK6
- Over 1,000-fold less potent against the cyclin B/CDK1 complex
- Induces cell-cycle arrest in G0/G1 phase
- Significantly delays tumor growth in neuroblastoma xenografts
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