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Apexbio Technology LLC Rifabutin 100mg
Supplier: Apexbio Technology LLC B2126100
Rifabutin is an antimycobacterial agent derived from rifamycin S belonging to the ansamycin antibiotic class It acts by binding to bacterial RNA polymerase inhibiting RNA synthesis and thus suppressing mycobacterial replication Rifabutin exhibits inhibitory activity against Mycobacterium tuberculosis strains with reported minimum inhibitory concentrations (MICs) typically ranging between 0 125 and 0 25 g/ml Due to its bacterial membrane affinity mediated through electrostatic interactions with phospholipid headgroups Rifabutin has attracted research interest in tuberculosis treatment models Experimentally its administration in murine tuberculosis infection models reduced bacterial load in lung liver and spleen tissues It is additionally investigated in clinical contexts particularly to manage tuberculosis infections in immunocompromised hosts including organ transplant recipients
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