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Apexbio Technology LLC Rifaximin (Xifaxan) 80621-81-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A85125.1
Rifaximin (Xifaxan) a rifamycin derivative is a nonabsorbable antibiotic targeting bacterial RNA synthesis by binding to the -subunit of bacterial DNA-dependent RNA polymerase In vitro rifaximin also functions as an intestinal-specific agonist for human pregnane X receptor (PXR) modulating intestinal immune responses Rifaximin (EC50 20 M) activates human PXR reducing inflammatory cytokine expression induced by LPS in human colonic biopsies In animal models rifaximin alters intestinal expression of PXR-responsive genes relevant to drug metabolism and lipid homeostasis Clinically rifaximin has been utilized in research on hepatic encephalopathy and irritable bowel syndrome (IBS)
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