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AdipoGen RIG-I mAb Alme-1Biotin
SDP

Supplier:  AdipoGen AG20B0009BC100

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Monoclonal Antibody. Recognizes human and mouse RIG-I. Isotype Mouse IgG1. Clone Alme-1. Applications IHC, IP, WB. Liquid. In PBS containing 0.02% sodium azide. RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5’-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains CARD and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta Cardif in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.

Catalog No. 50-256-3386


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