Apexbio Technology LLC Rigosertib sodium salt 1225497-78-8 25mg

Supplier:  Apexbio Technology LLC A140425

Rigosertib sodium salt (CAS 1225497-78-8) is a selective inhibitor targeting Polo-like kinase 1 (PLK1) with reported IC50 approximately 9 nM The compound notably decreases proliferation of cancer cell lines demonstrating nanomolar IC50 values in HeLa (115 nM) and C33A (45 nM) cells whereas normal cells (e g BJ and Ect1/E6E7) remain largely unaffected At concentrations exceeding 0 5 M rigosertib robustly induces G2/M phase arrest in cancer cells without significant cell cycle disruption at lower doses Additionally in vivo studies suggest its potential as a radiosensitizer in cervical carcinoma research

Catalog No. 50-000-63214