Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Rilmenidine (hemifumarate) 207572-68-7 5mg
Supplier: Apexbio Technology LLC C39655
Rilmenidine (hemifumarate CAS 207572-68-7) is an antihypertensive small molecule that primarily acts as an agonist at imidazoline I1 receptors within the rostral ventrolateral medulla thereby inhibiting the tonic activity of sympathoexcitatory neurons and reducing arterial pressure In vitro assays show that rilmenidine displays approximately 30-fold selectivity for imidazoline versus 2-adrenergic binding sites and a Ki of 7 1 nM for I1 receptors with significantly lower affinity for I2 sites (Ki 5 2 M) In vivo studies indicate efficacy in lowering blood pressure and ameliorating features of metabolic syndrome in rodent models as well as inducing autophagy and attenuating neurodegenerative pathology in a mouse model of Huntington s disease supporting its utility in cardiovascular and neurodegenerative research
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?