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Apexbio Technology LLC Rilmenidine Phosphate 85409-38-7 25mg
Supplier: Apexbio Technology LLC B496825
Rilmenidine phosphate (CAS 85409-38-7) is a water-soluble derivative of rilmenidine that selectively targets imidazoline I1 receptors non-adrenergic high-affinity binding sites implicated in blood pressure regulation Activation of I1 receptors modulates sympathetic outflow resulting in antihypertensive effects observed in both preclinical models and clinical studies In Hep G2 cells rilmenidine attenuates stearic acid-induced lipid accumulation associated with p38 MAPK activation and increased FXR expression In high-fat diet-fed mice rilmenidine ameliorates hepatic steatosis through imidazoline I1 receptor-mediated pathways This compound is of interest for investigating cardiovascular and metabolic disease mechanisms
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