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AdipoGen Rilpivirine
SDP

Supplier:  AdipoGen AGCR13750M025

Encompass_Preferred

Chemical. CAS 500287-72-9. Formula C22H18N6. MW 366.4. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor NNRTI that inhibits growth of wild-type HIV with an EC50 value of 0.51nM. It is active against NNRTI-resistant HIV strains with EC50 values less than 1nM for L100I, K103N, V106A, G190A and G190S mutants in vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates EC50s = <10nM, including strains containing up to eight resistance mutations. NNRTIs work by binding to and blocking HIV reverse transcriptase, which prevents HIV from replicating and lowers the amount of HIV in the blood. Rilpivirine is an antiviral anti-HIV drug, active against wild-type and NNRTI-resistant HIV-1 with higher potency, longer half-life and reduced side-effect profile compared with Efavirenz Prod. No. AG-CR1-3751. CARD8 inflammasome senses HIV-1 protease activity.

Catalog No. 50-256-2186


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