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Apexbio Technology LLC Riluzole 1mL DMSO
SDP

Supplier:  Apexbio Technology LLC A85135.1

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Riluzole (CAS 1744-22-5) is a small molecule modulator of glutamatergic neurotransmission exhibiting multiple mechanisms of neuroprotection Its action primarily involves inhibition of voltage-gated sodium channels modulation of high-voltage-activated calcium and potassium channels and interference with protein kinase C activity collectively mitigating neuronal excitotoxicity In cultured rat cortical neurons riluzole inhibits inward sodium currents with an IC50 of 51 M At submicromolar to micromolar concentrations riluzole enhances sodium-dependent glutamate uptake mediated by the GLAST GLT1 and EAAC1 transporters Owing to these properties riluzole is commonly utilized in neuroscience research on excitotoxicity neurodegeneration and related pathologies

Catalog No. 50-000-61936


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