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Medchemexpress LLC RIP1 kinase inhibitor 1 | 2095515-38-9 | 100.0% | 461.90 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY11140950MG

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RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04). It strongly suppresses necroptotic cell death and phosphorylation of MLKL (pMLKL) in human colorectal adenocarcinoma HT-29 cells (necroptosis, IC50=2 nM; pMLKL, IC50=1.3 nM) as well as mouse L-cells NCTC 929 (necroptosis, IC50=15 nM; pMLKL, IC50=2.7 nM).

  • Highly potent RIP1 kinase inhibitor
  • Orally available
  • Brain-penetrating
  • Suppresses necroptotic cell death
  • Suppresses phosphorylation of MLKL (pMLML)

Catalog No. 50-003-43704


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