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Medchemexpress LLC RIP1 kinase inhibitor 1 | 2095515-38-9 | 100.0% | 461.90 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY111409100MG

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RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04). It strongly suppresses necroptotic cell death and phosphorylation of MLKL (pMLKL) in human colorectal adenocarcinoma HT-29 cells (necroptosis, IC50=2 nM; pMLKL, IC50=1.3 nM) as well as mouse L-cells NCTC 929 (necroptosis, IC50=15 nM; pMLKL, IC50=2.7 nM). This inhibitor is designed for high-speed applications.

  • Highly potent and orally available
  • Brain-penetrating RIP1 kinase inhibitor
  • Strongly suppresses necroptotic cell death
  • Inhibits phosphorylation of MLKL (pMLKL)
  • Effective in human colorectal adenocarcinoma HT-29 cells
  • Effective in mouse L-cells NCTC 929

Catalog No. 50-003-44014


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