Medchemexpress LLC RIP1 kinase inhibitor 1 | 2095515-38-9 | 99.96% | 461.90 | 100 MG

Supplier:  Medchemexpress LLC HY11140910MM/1ML

RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor with a pKi of 9.04. It strongly suppresses necroptotic cell death and phosphorylation of MLKL (pMLKL) in human colorectal adenocarcinoma HT-29 cells (necrosis, IC50=2 nM; pMLKL, IC50=1.3 nM) as well as mouse L-cells NCTC 929 (necrosis, IC50=15 nM; pMLKL, IC50=2.7 nM).

• Highly potent RIP1 kinase inhibitor.
• Orally available.
• Brain-penetrating.
• Suppresses necroptotic cell death in human HT-29 cells (IC50=2 nM).
• Suppresses phosphorylation of MLKL in human HT-29 cells (IC50=1.3 nM).
• Suppresses necroptotic cell death in mouse L929 cells (IC50=15 nM).
• Suppresses phosphorylation of MLKL in mouse L929 cells (IC50=2.7 nM).

Catalog No. 50-003-43442