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Medchemexpress LLC Ripk1-in-4 | 1481641-08-0 | 98.89% | 401.46 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY18901100MG

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RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase. It binds to a DLG-out inactive form of RIP1 with IC50s of 16 nM for RIP1 and 10 nM for ADP-Glo kinase. This compound is intended for research use only.

  • Potent and selective type II kinase inhibitor
  • Targets receptor interacting protein 1 (RIP1) kinase
  • Binds to a DLG-out inactive form of RIP1
  • Inhibits autophosphorylation of RIP1 kinase domain with an IC50 of 0.01 μM
  • Prevents TNFalpha/zVAD.fmk-induced necrotic cell death

Catalog No. 50-003-85493


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