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Medchemexpress LLC RIPK1-IN-4 | 1481641-08-0 | 98.9% | 401.46 | C23H23N5O2 | 10 MG
Supplier: Medchemexpress LLC HY1890110MG
A potent, selective type II kinase inhibitor of receptor-interacting protein 1 (RIP1) that binds the DLG-out inactive conformation. It exhibits low-nanomolar biochemical potency (RIP1 IC50 16 nM; ADP-Glo IC50 10 nM) and shows cellular activity against RIP1-mediated necroptosis, making it suitable as a research tool for studies of RIP1 signaling and necroptosis.
- Potent biochemical inhibition of RIP1 (IC50 16 nM).
- Low-nanomolar ADP-Glo kinase activity (IC50 10 nM).
- Cellular efficacy in necroptosis models (L929, U-937).
- High purity and white to off-white solid appearance.
- High DMSO solubility (250 mg/mL) with ultrasonic assistance.
- Stable when stored per recommended conditions (powder and solvent).
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