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Medchemexpress LLC RIPK3-IN-1 | 2361139-70-8 | 99.3% | 100 MG
SDP

Catalog No. 5000341054
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RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. It inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM, respectively. It also acts as a c-Met kinase inhibitor with an IC50 of 1.1 μM. In vitro, RIPK3-IN-1 also inhibits ABL, BRAF/V599E, MAP4K3, and SRC with IC50s of 0.37, 0.15, 0.012, and 0.075 μM, respectively.

  • Inhibits RIPK3 with high potency
  • Targets RIPK1 and RIPK2
  • Acts as a c-Met kinase inhibitor
  • Exhibits additional inhibitory activity against ABL, BRAF/V599E, MAP4K3, and SRC
  • Useful for studying necroptosis, a programmed form of cell death
  • Relevant for research into various diseases including ischemia reperfusion injury, neurodegenerative disorders, pancreatic cancer, and autoimmune diseases like inflammatory bowel disease (IBD)

Catalog No. 50-003-41054 Supplier Medchemexpress LLC Supplier No. HY131064100MG
May include imposed supplier surcharges.
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RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. It inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM, respectively. It also acts as a c-Met kinase inhibitor with an IC50 of 1.1 μM. In vitro, RIPK3-IN-1 also inhibits ABL, BRAF/V599E, MAP4K3, and SRC with IC50s of 0.37, 0.15, 0.012, and 0.075 μM, respectively.

  • Inhibits RIPK3 with high potency
  • Targets RIPK1 and RIPK2
  • Acts as a c-Met kinase inhibitor
  • Exhibits additional inhibitory activity against ABL, BRAF/V599E, MAP4K3, and SRC
  • Useful for studying necroptosis, a programmed form of cell death
  • Relevant for research into various diseases including ischemia reperfusion injury, neurodegenerative disorders, pancreatic cancer, and autoimmune diseases like inflammatory bowel disease (IBD)

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