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Ristocetin Sulfate Salt, MP Biomedicals™

Catalog No. MP219548925 Shop All MP Biomedicals, Inc Products
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MP219548925 25 mg
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Description

Active against gram-positive and gram-negative bacteria. Ristocetin Sulfate Salt, MP Biomedicals is an antibiotic that belongs to the class III glycopeptides. It can be used in chromatography. Ristocetin has platelet aggregating activity and has been used

Ristocetin A is structurally related to the glycopeptide antibiotics Teicoplanin and vancomycin. It activates platelets and has been used in platelet aggregation studies.

  • Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis
  • Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia
  • Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes supporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals
  • Studies have demonstrated that Ristocentin A dimerizes and creates two binding sites for cell wall peptides
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1404-55-3
Molecular Formula C95H112N8O48S
Molecular Weight (g/mol) 2166.009
InChI Key HHRPQUHYQBGHHF-ADHWPEJWSA-N
Synonym Ristomycin monosulfate
PubChem CID 46783382
SMILES CC1C(C(CC(O1)OC2C3C(=O)NC(C4=CC(=CC(=C4C5=C(C=CC(=C5)C(C(=O)N3)NC(=O)C6C7=CC(=C(C(=C7)OC8=CC=C2C=C8)OC9C(C(C(C(O9)COC1C(C(C(C(O1)C)O)O)O)O)O)OC1C(C(C(C(O1)CO)O)O)OC1C(C(C(CO1)O)O)O)OC1=CC=C(C=C1)C(C1C(=O)NC(C2=CC(=C(C(=C2)O)C)OC2=C(C=CC(=C2)C(C(=O)N1)N)O)

Specifications

Physical Form Powder
Quantity 25 mg
Solubility Information Soluble in 1 N HCl (50mg/mL - clear and colorless to pale yellow); soluble in water (clear 5mg+ 0.25mL, amber solution).
Formula Weight 2166.0
Percent Purity ≥90% Ristocetin A

Safety and Handling

Recommended Storage +4°C, protect from light.
WARNING: Cancer - www.P65Warnings.ca.gov
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