Ristocetin Sulfate Salt, MP Biomedicals™

Description

Active against gram-positive and gram-negative bacteria. Ristocetin Sulfate Salt, MP Biomedicals is an antibiotic that belongs to the class III glycopeptides. It can be used in chromatography. Ristocetin has platelet aggregating activity and has been used

Ristocetin A is structurally related to the glycopeptide antibiotics Teicoplanin and vancomycin. It activates platelets and has been used in platelet aggregation studies.

• Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis
• Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia
• Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes supporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals
• Studies have demonstrated that Ristocentin A dimerizes and creates two binding sites for cell wall peptides

Specifications

Chemical Identifiers

• CAS: 1404-55-3
• Molecular Formula: C95H112N8O48S
• Molecular Weight (g/mol): 2166.009
• InChI Key: HHRPQUHYQBGHHF-ADHWPEJWSA-N
• Synonym: Ristomycin monosulfate
• PubChem CID: 46783382
• SMILES: CC1C(C(CC(O1)OC2C3C(=O)NC(C4=CC(=CC(=C4C5=C(C=CC(=C5)C(C(=O)N3)NC(=O)C6C7=CC(=C(C(=C7)OC8=CC=C2C=C8)OC9C(C(C(C(O9)COC1C(C(C(C(O1)C)O)O)O)O)O)OC1C(C(C(C(O1)CO)O)O)OC1C(C(C(CO1)O)O)O)OC1=CC=C(C=C1)C(C1C(=O)NC(C2=CC(=C(C(=C2)O)C)OC2=C(C=CC(=C2)C(C(=O)N1)N)O)

• Physical Form: Powder
• Quantity: 25 mg
• Solubility Information: Soluble in 1 N HCl (50mg/mL - clear and colorless to pale yellow); soluble in water (clear 5mg+ 0.25mL, amber solution).
• Formula Weight: 2166.0
• Percent Purity: ≥90% Ristocetin A

Safety and Handling

Recommended Storage

+4°C, protect from light.

WARNING: Cancer - www.P65Warnings.ca.gov