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Apexbio Technology LLC Rivaroxaban 366789-02-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A43385.1
Rivaroxaban (CAS 366789-02-8) is a small molecule inhibitor targeting coagulation Factor Xa a serine protease essential in the thrombin generation pathway involved in clot formation It binds reversibly to the S1 pocket of Factor Xa engaging specifically through interactions between its chlorothiophene moiety and the Tyr288 residue Binding kinetics are rapid (kon 1 7 10 7 mol L 1 s 1 koff 5 10 3 s 1) and affinity is high (Ki 0 4 nmol/L) Rivaroxaban is studied extensively in thrombosis research including venous thromboembolism stroke prevention in atrial fibrillation and cardiovascular event management post-acute coronary syndrome
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