Cayman Chemical RIvastIgmIntartrate 100mg

Supplier:  Cayman Chemical 14270100 MG

A ChE inhibitor that inhibits BChE and AChE (IC50s = 0.037 and 4.15 μM, respectively); increases levels of sAPP and decreases levels of soluble amyloid-β (1-40) and various N-terminal cleavage products in primary embryonic rat neurons undergoing degeneration at 5 and 10 μM; inhibits formation of amyloid plaques in brain sections and increases in AChE, IL-1β, and BACE1 mRNA expression in the cerebral cortex at 1 mg/kg per day in a rat model of Alzheimer's disease induced by AlCl3; inhibits AlCl3-induced increases in escape latency time in the Morris water maze in a rat model of Alzheimer's disease at 1 mg/kg; reverses decreases in time spent in the open arms of an elevated plus maze, exploration time of a novel object in a novel object recognition test, and sucrose intake in a rat model of chronic mild stress at 2 mg/kg

Catalog No. 50-295-5855