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Medchemexpress LLC Rk-582 | 2171388-28-4 | 98.05% | 510.60 | 25 MG
Supplier: Medchemexpress LLC 25MGHY137849
RK-582 is a tankyrase inhibitor and an orally bioavailable growth inhibitor, acting as an antitumor agent. It is suitable for research on colorectal cancer. This compound potently inhibits human tankyrase-1 and tankyrase-2 catalytic activity with high selectivity over PARP1, PARP2, and PARP10. It also inhibits Wnt/β-catenin signaling and the growth of COLO-320DM human colorectal cancer cells.
- Inhibits tankyrase-1 and tankyrase-2 catalytic activity
- Demonstrates high selectivity over PARP1, PARP2, and PARP10
- Inhibits Wnt/β-catenin signaling
- Potently inhibits the growth of COLO-320DM human colorectal cancer cells
- Modulates Wnt/β-catenin signaling by stabilizing AXIN2 and reducing active β-catenin
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