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Medchemexpress LLC RK-582 | 2171388-28-4 | 98.1% | 510.60 | 100 MG
SDP

Catalog No. 5000350593
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RK-582 is an orally bioavailable tankyrase inhibitor and antitumor agent, demonstrating potent inhibition of human tankyrase-1 (IC50 36.1 nM) and tankyrase-2 (IC50 39.2 nM). Its efficacy in APC-mutated colorectal cancer cells correlates with active β-catenin levels, making it valuable for colorectal cancer research.

  • Potent tankyrase inhibitor.
  • Functions as an antitumor agent and orally bioavailable growth inhibitor.
  • Effective in APC-mutated colorectal cancer cells.
  • Demonstrates high selectivity over PARP1, PARP2, and PARP10.
  • Inhibits Wnt/β-catenin signaling.
  • Inhibits growth of COLO-320DM human colorectal cancer cells (GI50 = 0.035 μM).
  • Induces AXIN2 accumulation and reduces active β-catenin levels.

Catalog No. 50-003-50593 Supplier Medchemexpress LLC Supplier No. HY137849100MG
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RK-582 is an orally bioavailable tankyrase inhibitor and antitumor agent, demonstrating potent inhibition of human tankyrase-1 (IC50 36.1 nM) and tankyrase-2 (IC50 39.2 nM). Its efficacy in APC-mutated colorectal cancer cells correlates with active β-catenin levels, making it valuable for colorectal cancer research.

  • Potent tankyrase inhibitor.
  • Functions as an antitumor agent and orally bioavailable growth inhibitor.
  • Effective in APC-mutated colorectal cancer cells.
  • Demonstrates high selectivity over PARP1, PARP2, and PARP10.
  • Inhibits Wnt/β-catenin signaling.
  • Inhibits growth of COLO-320DM human colorectal cancer cells (GI50 = 0.035 μM).
  • Induces AXIN2 accumulation and reduces active β-catenin levels.

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