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Medchemexpress LLC Rki-1447 dihydrochloride | 1782109-09-4 | 99.9% | 399.29 | 10 MG
Supplier: Medchemexpress LLC HY11033910MG
RKI-1447 dihydrochloride is a potent and selective ROCK inhibitor, effectively suppressing colorectal carcinoma cell growth and promoting apoptosis. It functions by inhibiting ROCK1 (IC50 14.5 nM) and ROCK2 (IC50 6.2 nM), without affecting AKT, MEK, and S6 kinase phosphorylation. This compound has demonstrated significant anticancer activity in both in vitro and in vivo studies, including the inhibition of mammary tumor growth and antitumor effects in colorectal carcinoma.
- Potent and selective ROCK inhibitor
- Suppresses colorectal carcinoma cell growth
- Promotes apoptosis in a dose-dependent manner
- Inhibits phosphorylation of ROCK substrates MLC-2 and MYPT-1
- Exhibits anticancer activity in colorectal carcinoma (CRC)
- Inhibits mammary tumor growth in transgenic mice
- Shows antitumor activity in CRC without physiological toxicity
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