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Medchemexpress LLC RKI-1447 dihydrochloride | 1782109-09-4 | 99.9% | 399.29 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY110339100MG

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RKI-1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively. It suppresses colorectal carcinoma cell growth and promotes apoptosis.

  • Potent and selective ROCK inhibitor
  • Suppresses colorectal carcinoma cell growth
  • Promotes apoptosis
  • Suppresses phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells
  • Exhibits effective anticancer activity in colorectal carcinoma (CRC)
  • Inhibits mammary tumor growth in vivo
  • Does not exert physiological toxicity on mice in vivo

Catalog No. 50-003-43939


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