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Apexbio Technology LLC RN486 1242156-23-5 10mM (in 1mL DMSO)
SDP

Catalog No. 5000061794
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RN486 (CAS 1242156-23-5) is a reversible and selective inhibitor of Bruton s tyrosine kinase (BTK) an enzyme prominently expressed in immune cells including B lymphocytes and macrophages BTK participates critically in B-cell receptor (BCR) and Fc receptor (FcR) signaling pathways influencing B-cell differentiation proliferation and antibody production RN486 exhibits potent inhibitory effects (IC50 4 0 nM) and effectively diminishes signaling events B-cell activation and IgG synthesis in cellular assays In animal models RN486 suppresses autoimmune and inflammatory responses reducing disease progression in lupus (NZB NZW mice) and arthritis indicating its utility in autoimmune research

Catalog No. 50-000-61794 Supplier Apexbio Technology LLC Supplier No. A86365.1
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RN486 (CAS 1242156-23-5) is a reversible and selective inhibitor of Bruton s tyrosine kinase (BTK) an enzyme prominently expressed in immune cells including B lymphocytes and macrophages BTK participates critically in B-cell receptor (BCR) and Fc receptor (FcR) signaling pathways influencing B-cell differentiation proliferation and antibody production RN486 exhibits potent inhibitory effects (IC50 4 0 nM) and effectively diminishes signaling events B-cell activation and IgG synthesis in cellular assays In animal models RN486 suppresses autoimmune and inflammatory responses reducing disease progression in lupus (NZB NZW mice) and arthritis indicating its utility in autoimmune research

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