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New England Biolabs, Inc. RNase R – 400 units
SDP

Catalog No. 503025696
Encompass

Ribonuclease R (RNase R) is a processive 3' to 5' exoribonuclease. RNase R requires a 3' single-stranded RNA substrate that is approximately 10 nucleotides or longer, such as a poly(A) tail, for proper binding. RNase R is unique from other exoribonucleases for its ability to degrade highly structured RNAs without the need for an additional helicase. Circular RNAs and lariat RNAs are enriched after RNase R digestion as these closed RNA structures are resistant to exoribonucleases.

  • Highly processive 3' to 5' exoribonuclease
  • Digests nearly all linear RNAs with an accessible 3' end, including rRNA and mRNA
  • Enriches for circular RNAs and lariat RNAs from total RNA preps
  • Inactivated with the addition of excess EDTA

Catalog No. 50-302-5696 Supplier New England Biolabs, Inc. Supplier No. M0100S
May include imposed supplier surcharges.
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Ribonuclease R (RNase R) is a processive 3' to 5' exoribonuclease. RNase R requires a 3' single-stranded RNA substrate that is approximately 10 nucleotides or longer, such as a poly(A) tail, for proper binding. RNase R is unique from other exoribonucleases for its ability to degrade highly structured RNAs without the need for an additional helicase. Circular RNAs and lariat RNAs are enriched after RNase R digestion as these closed RNA structures are resistant to exoribonucleases.

  • Highly processive 3' to 5' exoribonuclease
  • Digests nearly all linear RNAs with an accessible 3' end, including rRNA and mRNA
  • Enriches for circular RNAs and lariat RNAs from total RNA preps
  • Inactivated with the addition of excess EDTA

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