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Cayman Chemical RnolazInhydrochlorIde 50mg
SDP

Supplier:  Cayman Chemical 1560450 MG

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A piperazine derivative with cardioprotective activity; reduces INa in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM); reduces IKr in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively); reduces clofilium-induced prolongation of the QTc interval and TdP in rabbits at 480 μg/kg per min; reduces interstitial collagen deposition as well as ANP, CTGF, BNP, and MMP-2 mRNA levels, and prevents left ventricular dilation in a mouse model of doxorubicin-induced cardiotoxicity

Catalog No. 50-296-9194


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