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Apexbio Technology LLC Ro 08-2750 37854-59-4 1mg
Supplier: Apexbio Technology LLC B69961
Ro 08-2750 (CAS 37854-59-4) is a small molecule antagonist of nerve growth factor (NGF) that selectively inhibits NGF binding to the p75 neurotrophin receptor (p75NTR) over TrkA With an IC50 of 1 M for NGF binding Ro 08-2750 induces a conformational change in NGF preventing its interaction with p75NTR while sparing TrkA association at lower concentrations In vitro studies demonstrate that Ro 08-2750 modulates NGF-mediated signaling including suppression of NGF-induced apoptosis in SK-N-MC cells and enhancement of TrkA pathway activity in PC12 cells This compound serves as a valuable tool for investigating the distinct roles of p75NTR and TrkA in neuronal apoptosis differentiation and axonal growth
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