Medchemexpress LLC Ro 08-2750 | 37854-59-4 | 98.01% | 270.24 | 10 MG

Supplier:  Medchemexpress LLC HY10846610MM/1ML

Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor that binds to NGF with an IC50 of approximately 1 μM. It selectively inhibits NGF binding to p75NTR over TRKA. Ro 08-2750 is also a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM.

• Binds to the NGF dimer, potentially inducing a conformational change that prevents NGF from binding to p75NTR.
• Completely rescues cells from NGF-induced SK-N-MC 103 cell death at 10 nM.
• Increases differentiation and apoptosis in myeloid leukemia cells at 5-10 μM (8 hours).
• Inhibits survival of human AML lines and patient cells.
• Inhibits MSI2 RNA-binding and alters MSI2 gene signature.
• Inhibits leukemogenesis in a myeloid leukemia model in vivo at 13.75 mg/kg (i.p.).
• Reduces c-MYC levels and disease burden in a myeloid leukemia model.

Catalog No. 50-003-45453