Apexbio Technology LLC Ro 31-8220 125314-64-9 50mg

Supplier:  Apexbio Technology LLC B128750

Ro 31-8220 (CAS 125314-64-9) is a potent and selective inhibitor of protein kinase C (PKC) targeting isoforms PKC- (IC50 5 nM) PKC- I (24 nM) PKC- II (14 nM) PKC- (27 nM) and PKC- (24 nM) PKC is a Ca2 and phospholipid-dependent serine/threonine kinase involved in signaling pathways regulating cell proliferation and malignancy Ro 31-8220 modulates downstream signaling by inducing c-Jun expression and activating JNK1 while inhibiting MKP-1 and c-Fos expression independent of PKC activity In immunological studies it suppresses IL-2 production (IC50 80 nM) T cell proliferation (IC50 350 nM) and CD25 expression indicating inhibition of both early and late T cell activation Ro 31-8220 is widely utilized in cellular and molecular studies to dissect PKC-dependent and independent signaling mechanisms

Catalog No. 50-000-90392