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Medchemexpress LLC Ro 48-8071 | 189197-69-1 | 99.1% | 564.44 | 100 MG
Supplier: Medchemexpress LLC HY18630A100MG
Ro 48-8071 is an inhibitor of Oxidosqualene cyclase (OSC) with an IC50 of approximately 6.5 nM. It is intended for research use only.
- Inhibits cholesterol synthesis in HepG2 cells (IC50 ~1.5 nM).
- Reduces viability of PC-3 prostate cancer cells, not normal prostate cells.
- Induces apoptosis in LNCaP, C4-2, castration-resistant PC-3, and DU145 cell lines.
- Reduces AR protein expression; increases ERβ protein expression dose-dependently.
- Inhibits 17β-estradiol (E2)-induced ERα responsive luciferase activity (IC50 ~10 μM).
- Lowers LDL-C by ~60% in hamsters without affecting HDL-C.
- Increases MOS in liver; significantly reduces VLDL secretion in hamsters.
- Reduces in vivo tumor growth in mice without weight loss; can eradicate tumors.
- Sustains and selectively suppresses intestinal cholesterol synthesis in BALB/c mice.
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