Medchemexpress LLC Ro 48-8071 Fumarate | 189197-69-1 | 99.1% | 564.44 | 1 ML

Supplier:  Medchemexpress LLC HY18630A10MM/1ML

Ro 48-8071 is an inhibitor of Oxidosqualene cyclase (OSC) with an IC50 of approximately 6.5 nM. This compound is intended for research use only and is not sold for patient treatment. It has demonstrated efficacy in reducing cholesterol synthesis and inducing apoptosis in various cancer cell lines, as well as inhibiting tumor growth in vivo.

• Inhibits Oxidosqualene cyclase (OSC) with an IC50 of approximately 6.5 nM.
• Reduces cholesterol synthesis with an IC50 of approximately 1.5 nM in HepG2 cells.
• Significantly reduces viability of PC-3 prostate cancer cells.
• Induces apoptosis in LNCaP and C4-2 cell lines.
• Reduces AR protein expression and increases ERβ protein expression.
• Lowers LDL-C maximally by approximately 60% in hamsters.
• Significantly reduces in vivo tumor growth in mice.

Catalog No. 50-003-88114