Medchemexpress LLC Ro-5963 | 1416663-77-8 | 98.2% | 50 MG

Supplier:  Medchemexpress LLC HY12008650MG

RO-5963 is a small-molecule dual inhibitor of p53-MDM2 and p53-MDMX that activates the p53 pathway and induces apoptosis in cancer cell lines. It exhibits nanomolar potency and has demonstrated increased apoptotic activity compared with Nutlin in MCF7 and ZR75-30 cells.

• Dual p53-MDM2 and p53-MDMX inhibition (IC50 ≈ 17 nM and 24 nM)
• High in vitro potency and apoptosis induction in breast cancer cell lines
• Soluble in DMSO at 150 mg/mL for in vitro use
• Available as solids in multiple milligram sizes and as DMSO solutions
• Recommended storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months)

Catalog No. 50-002-31839