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Apexbio Technology LLC Ro3280 1062243-51-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A86815.1
Ro3280 (CAS 1062243-51-9) is a selective small-molecule inhibitor targeting Polo-like kinase 1 (PLK1) exerting inhibitory activity with an IC50 of 3 nM PLK1 is a cell cycle kinase involved prominently in regulating progression from G2 to M phase frequently overexpressed in various malignancies Ro3280 inhibits PLK1 activity and induces apoptosis and cell cycle disruption in acute leukemia cell lines (e g U937 HL-60 NB4 K562 MV4-11) and diverse solid tumor models (e g lung carcinoma H82 colon carcinoma HT-29 breast carcinoma MDA-MB-468) In mouse xenografts of HT-29 tumors Ro3280 demonstrates significant tumor regression highlighting its potential in cancer therapeutics research
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