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TARGETMOL CHEMICALS INC RO5-3335 10MG
Supplier: TARGETMOL CHEMICALS INC T468710MG
Also available in 5 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Ro5-3335 (CBF(beta)-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 uM). Ro5-3335 represses RUNX1/CBF(beta)-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBF(beta). Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro. purity: 99%
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