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Medchemexpress LLC Ro5-3335 | 30195-30-3 | 99.35% | 259.69 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY108470100MG

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Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. It is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation.

  • Exhibits antiproliferative activity against human CBF leukemia cell lines.
  • Inhibits definitive hematopoiesis in zebrafish embryos.
  • Modifies the conformation or increases the distance between the components of the RUNX1-CBFβ complex.
  • Identified as an inhibitor of RUNX1-CBFβ function in zebrafish models.
  • Rescues preleukemic phenotype in transgenic zebrafish.
  • Reduces leukemia burden in a mouse leukemia model.

Catalog No. 50-003-44997


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