Apexbio Technology LLC RO5126766(CH5126766) 946128-88-7 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B58205.1

RO5126766 (CH5126766 CAS 946128-88-7) is a dual Raf/MEK inhibitor that targets the RAS/RAF/MEK/ERK signaling pathway involved in cellular proliferation survival and differentiation By inhibiting RAF-dependent MEK1 phosphorylation and subsequent MEK-mediated ERK activation RO5126766 suppresses downstream signaling In vitro kinase assays show IC50 values of 0 0082 0 056 M for MEK1 phosphorylation and 0 16 M for MEK1-induced ERK2 activation Studies in KRAS-mutant cancer cell lines such as HCT116 and NCI-H460 demonstrate that RO5126766 blocks MEK and ERK phosphorylation effectively inducing cell cycle arrest at the G1 stage Thus RO5126766 serves as a valuable research tool for investigating tumor biology driven by MAPK signaling dysregulation

Catalog No. 50-000-63584