Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000092244

Apexbio Technology LLC Rofecoxib 162011-90-7 250mg
SDP

Supplier:  Apexbio Technology LLC B1454250

Encompass_Preferred

Rofecoxib (CAS 162011-90-7) is a selective inhibitor of cyclooxygenase-2 (COX-2) designed to provide anti-inflammatory effects with improved gastrointestinal tolerance compared to non-selective NSAIDs It demonstrates potent inhibition of COX-2 in cell-based assays with IC50 values ranging from 18 to 46 nM In osteosarcoma cells Rofecoxib suppresses prostaglandin E2 (PGE2) synthesis (IC50 26 nM) and inhibits recombinant human COX-2 in stably transfected CHO cells (IC50 18 nM) In biochemical assays using purified human COX-2 the IC50 is 0 34 M In vivo Rofecoxib reduces carrageenan-induced edema and hyperalgesia in rats (ID50 1 1 5 mg/kg) It is widely used in studies investigating COX-2-mediated inflammatory pathways and analgesia

Catalog No. 50-000-92244


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.