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Medchemexpress LLC Rofecoxib-d5 | 544684-93-7 | 319.39 | 500 UG
Supplier: Medchemexpress LLC HY17372S500UG
Rofecoxib-d5 is a deuterium-labeled variant of Rofecoxib, a potent and orally active COX-2 inhibitor. It exhibits high selectivity for COX-2 over human COX-1, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, respectively, and an over 1000-fold selectivity for COX-2 compared to human COX-1 in U937 cells and Chinese hamster ovary cells.
- Can be utilized as a tracer in various applications.
- Serves as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
- Incorporation of stable heavy isotopes like deuterium can influence the pharmacokinetic and metabolic profiles of compounds.
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